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MELISA® is the registered trademark of MELISA MEDICA FOUNDATION

MELISA stands for "Memory Lymphocyte Immunostimulation Assay", an "in vitro" test for metal allergy.

What MELISA provides is a reliable, objective means for determining individual immune system sensitivity to specific metals, and metal compounds.

Mercuric compounds such as phenylmercury and thimerosal are commonly used as preservatives in vaccines, root fillings, contact lense solutions, nose drops, and other preparations.

It is now known that a subset of the population develops memory lymphocytes specific to these and other metal compounds. Being injected with such a compound when one is immune sensitized can cause severe complications ranging from unexplained fatigue to anaphylactic shock, and even death.

This information is a critical missing piece in understanding a likely pathology of Gulf War Syndrome, "amalgam disease", CFIDS , and autoimmune conditions.

Below you will find a journal reference regarding work done with the MELISA test. We have created a graph from the authors published data to better visualize the study results.

For contact information and other important information concerning MELISA® test for metal allergy, visit the web site:

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Title
Human Hapten-Specific Lymphocytes: Biomarkers of Allergy in Man
Author
Vera D. M. Stejskal, Ph.D.
Source
Drug Information Journal, Vol. 31, pp. 1379-1382, 1997
Abstract
Environmental pollutants and other chemicals may have increasing impact on the immune systems of human beings. Disregulation of the immune system by chemicals may be one of the reasons why the frequency of allergies and autoimmune diseases increases. Human hapten-specific memory lymphocytes can be detected in the blood from patients with drug-induced immunologic side-effects but not in similarly exposed healthy individuals.

The immune reactivity of human lymphocytes in vitro to white coloring agent--titanium dioxide (TiO2), and to mercurial conservatives thimerosal and phenylmercury--has been studied. It was found that out of 650 patients tested, 3% reacted to titanium dioxide. The percentages for phenylmercury and thimerosal were 14% and 7%, respectively. Human memory cells can be used as markers of susceptibility in future choices of appropriate additives in pharmaceutic products.