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1 - bottle, 90 capsules, 500mg - hist90
or call toll free 1-888-801-2376

Each Capsule Contains: L-histidine 500 mg, glycerin.

* This product is not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, lactating, suffer from diabetes, neurological disorders, autoimmune problems, or any other serious illness, please consult your physician before using this product.
These statements have not been reviewed by the FDA.

Made to USP standards for quality, purity, and potency. This product is free of yeast, sugar, lactose and gluten.

Scientific References

L-histidine* is an essential amino acid that cannot be formed by other nutrients, and must be in the diet to be available to the body.

Most often recognized as a precursor to the allergy symptom producing hormone histamine, both histidine and histamine have essential roles in the body beyond tormenting allergy sufferers.

Histamine is well known for its role in stimulating the inflammatory response of skin and mucous membranes such as those found in the nose - this action is essential in the protection of these barriers during infection.

Histamine also stimulates the secretion of the digestive enzyme gastrin. Without adequate histamine production healthy digestion can become impaired. Without adequate L-histidine stores, the body cannot maintain adequate histamine levels.

Less well known is that L-histidine is required by the body to regulate and utilize essential trace minerals such as copper, zinc, iron, manganese and molybdenum.

L-histidine is essential in forming many metal bearing enzymes and compounds, examples being the antioxidant super oxide dismutase, the iron storage protein ferritin, the iron uptake regulation protein -FUR, the copper storage and iron metabolism cofactor cerulplasmin, red blood cell hemoglobin, the toxic metal storage protein metallothionein, and the cysteine regulating enzyme cysteine dioxygenase - to name but a few important enzymes dependent on L-histidine being available for formation and function.

Metals such as zinc, copper and nickel are transported by binding with L-histidine, and such binding appears essential for rapid excretion of excess metal.

Toxic metals such as mercury, lead, cadmium, and threatening excesses of essential minerals zinc and copper stimulate the rapid formation of metallothionein inside cells of the brain, liver, and kidneys.

Metallothionein is a molecule designed to store metals in such a way as to prevent uncontrolled oxidation reactions - protecting the normal workings of the cell. Metallothionein requires both L-cysteine (usually derived from available glutathione stores) and L-histidine to be formed.

Persons contaminated with heavy metals, suffering from chronic seasonal allergies, or following a low histidine diet are most susceptible to body depletion of adequate histidine stores - creating the possibility of mineral-enzyme deficiencies and dysregulation.

Depletion of body stores of L-histidine might be best recognized by dysfunction of L-histidine dependent compounds, and low blood plasma concentrations of the amino acid.

High blood serum levels of iron have been experimentally caused in humans by a diet low in L-Histidine.

Intolerance of sulfur bearing foods like garlic and broccoli along with elevated blood plasma L-cysteine levels indicate inactivation of the L-Histidine and iron dependent enzyme cysteine dioxygenase.

As with most free form amino acids, L-histidine absorption is best when taken between meals without food and without accompanying minerals.

If you are taking other amino acids such as those found in our Defense Formula, L-Histidine should be taken at the same time as these.

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